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Toronto Notes 2019
Common Medications
Obstetrics OB49
Common Medications
Table 25. Common Medications
Drug Name (Brand Name)
betamethasone valerate (Celestone®) carboprost (Hemabate®)
cefazolin
clindamycin
dexamethasone
dinoprostone (Cervidil®: PGE2 impregnated thread)
doxylamine succinate (Diclectin®)
erythromycin folic acid
methotrexate
methylergonavine maleate (Ergotamine®)
misoprostol (Cytotec®) oxytocin (Pitocin®)
Penicillin G
PGE2 gel (Prostin® gel) Rh IgG (Rhogam®)
Dosing Schedule
12mgIMq24hx2doses
0.25 mg IM/IMM q15min Max2mg
2gIVthen1gq8h
900 mg IV q8h
6mgIMq12hx4doses
10 mg PV (remove after 12 h) Max 3 doses
2 tabs qhs + 1 tab qam + 1 tab qpm Max 8 tabs/d
500 mg IV q6h
0.4-1 mg PO OD x 1-3 mo preconception and T1 5 mg PO OD with past Hx of NTD/risks for NTD
50 mg/mL IM or 50 mg PO x 1 dose
0.25 mg IM/IMM q15min up to 1.25 mg or IV bolus 0.125 mg
600-1000 μg PR x 1 dose
400 μg PO/SL x 1 dose
or 800 μg PV x 1 dose 3-7 d after methotrexate
0.5-2.0 mU/min IV or 10 U/L NS increase by 1-2 mU/min q20-60min Max 36-48 mU/min
10 IU IM at delivery of anterior shoulder and of placenta
20 IU/L NS or RL IV continuous infusion
5 million IU IV, then 2.5 million IU IV q4h until delivery 0.5 mg PV q6-12h; max 3 doses
300 μg IM x 1 dose
Indications/Comments
Enhancement of fetal pulmonary maturity for PTL Treatment of uterine atony
GBS prophylaxis (penicillin allergic and not at risk for anaphylaxis) Used in endometritis
Enhancement of fetal pulmonary maturity for PTL
Induction of labour
Advantage: can remove if uterine hyperstimulation
Each tablet contains 10 mg doxylamine succinate with vitamin B6 Used for hyperemesis gravidarum
GBS prophylaxis (penicillin allergic and at risk for anaphylaxis) Prevention of ONTD
For ectopic pregnancy or medical abortion Treatment of uterine atony
For treatment of PPH
For medical abortion/retained products of conception
Augmentation of labour (also induction of labour) Prevention of uterine atony
Treatment of uterine atony
GBS prophylaxis
Induction of labour
Given to Rh negative women
Routinely at 28 wk GA
Within 72 h of birth of Rh+ fetus
Positive Kleihauer-Betke test
With any invasive procedure in pregnancy
Ectopic pregnancy
Antepartum hemorrhage
Miscarriage or therapeutic abortion (dose: 50 μg IM only)